1 What Is This Book About？
1.1 Note on Nomenclature
2 Chemicals from Metabolic Pathways
2.1 The Bioreflnery
2.1.1 Ethanol Production
2.1.2 Producfion of P1atform Chemicals in the Biorefinery
2.2 The Chemistry of Metabolic Pathways
2.2.1 The Currencies Of Gibbs Free Energy and of Reducing Power
2.2.2 Glycolysis
2.2.3 Fermentative Metabolism：Oxidation of NADH in Anaerobic Processes
2.2.4 The TCA Cycle：Provider of Building Blocks and NADH／FADH，
2.2.5 Production of ATP bv 0xidative Phosphorylation
2.2.6 The Pentose Phosphate Pathway：A Multipurpose Metabolic Network
2.2.7 Summary of the Primary Metabolism of Glucose
2.3 Examples of Industrial Production 0f Chemicals by Bioprocesses
2.3.1 Amino Acids
2.3.2 Antibiotics
2.3.3 Secreted Proteins
2.4 Design of Biotech Processes：Criteria for Commercial Success
2.4.1 Strain Design and Selection
2.4.2 Criteria for Design and Optimization of a Fermentation Process
2.4.3 Strain Improvement
2.5 T11e Prospects of the Biorefmery
Problems
References
3 Elemental and Redox Balances
3.1 The Continuous.Stirred Tank Reactor
3.1.1 Mass Balances for all Ideal.SteadY-State Corninuous Tank Reactor
3.2 Yield Coefncients
3.3 Black BOX Stoichiometries
3.4 Degree of Reduction Balances
3.4.1 Consistency Test of Experimental Data
3.4.2 Redox Balances Used in the Design of Bioremediation Processes
3.5 Systematic Analysis of Black BOX Stoichiometries
3.6 Identification of Gross Measurement Errors
Problems
References
4 Thermodynamics OfBioreactions
4.1 Chemical Equilibrium and Thermodynamic State Functions
4.1.1 Changes in Free Energy and Enthalpy
4.1.2 Free Energy Changes in Bioreactions
4.1.3 Combustion：A Change in Reference State
4.2 Heat ofReaction
4.2.1 Nonequilibrium Thermodynamics
4.2.2 Free Energy Reclaimed by Oxidation in the E1ec on Transfer Chajn
4.2.3 Production of ATP Mediated by F0一F1 ATP Synthase
Problems
References
5 Biochemical Reaction Networks
5.1 Basic Concepts
5.1.1 Metabolic Network with Diverging Branches
5.1.2 A FormalMatrix .Based Description of Metabolic Networks
5.2 Growth Energetics
5.2.1 Consumption of ATP for Cellular Maintenance
5.2.2 Energetics ofAnaerobic Processes
5.2.3 Energetics ofAerobic Processes
……
6 Enzyme Kinetics and Metabolic Control Analysis
7 Growth Kinetics ofCell Cultures
8 Population Balance Equations
9 Design of Fermentation Processes
10 Gas-Liquid Mass Transfer
11 Scale-Up ofBioprocesses
Index
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