Preface
cknowledgements
Dedication
Part Ⅰ:Metabolic Processes and Nutrition
1. Overview of Metabolism
Useful definitions
Basic principles of bioenergetics
2. Carbohydrate and Energy Metabolism
Glycolysis and its regulation
Central role of acetyl CoA
The tricarboxylic acid cycle
Generation of ATP
Glycogen metabolism
Role of 2,3-bisphosphoglycerate
Fructose, galactose, ethanol and sorbitol
3. Production of NADPH
Pentose phosphate pathway and pyruvate-malate cycle
The roles of NADPH
4. Lipid Metabolism and Transport
Lipid biosynthesis
Lipid breakdown
Cholesterol metabolism
Transport of lipids
Ketone bodies and ketogenesis
5. Protein Metabolism
Biosynthesis of non-essential amino acids
Protein breakdown and the disposal of nitrogen
Formation of glucose from non-carbohydrate sources
Disorders of amino acid metabolism
Amino acid metabolism in individual tissues
6. Purines, Pyrimidines and Haem
One-carbon pool
Purine metabolism
Pyrimidine metabolism
Haem metabolism
7. Glucose Homeostasis
The states of glucose homeostasis
Diabetes mellitus
8. Nutrition
Basic principles of human nutrition
Energy balance
Protein nutrition
Vitamins
Minerals
Part Ⅱ:Clinical Assessment of Metabolic Disease
9. Common Presentations of Metabolic Disease
Common presenting
complaints
10. History and Examination
Things to remember when taking a history
Communication skills
Examination
11. Further Investigations
Routine investigations
Assessment of nutritional status
Part Ⅲ:Self-assessment
Multiple-choice Questions （MCQs）
Short-answer Questions （SAQs）
Essay Questions
MCQ Answers
SAQ Answers
Index
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