硒蛋白及其模拟物(英文版)

目 录内容简介
1 Glutathione Peroxidases
1.1 Introduction
1.2 Glutathione Peroxidase Reaction
1.2.1 Basic Catalytic Principle
1.2.2 Kinetics
1.2.3 Physiological Consequences of Kinetic Mechanism
1.2.4 Facts, Unknowns and Guesswork
1.3 Biological Roles of Individual Glutathione Peroxidases
1.3.1 GPx1
1.3.2 GPx2
1.3.3 GPx3
1.3.4 GPx4
1.3.5 GPx5-GPx8
1.4 Conclusions and Perspectives
References
2 Thyroid Hormone Deiodinases
2.1 Introduction
2.2 Thyroid Hormones
2.3 Deiodinases
2.3.1 Structure
2.3.2 Control
2.4 Role of Deiodinase in TH Actions
2.4.1 Photoperiod
2.4.2 Nutrition
2.4.3 Thermogenesis
2.4.4 Osmoregulation
2.4.5 Reproduction
2.4.6 Development, Including Metamorphosis
2.4.7 Developmental Genes
2.5 Evolution
References
3 Thioredoxin Reductase
3.1 Introduction
3.2 Selenium in Mammalian TrxR
3.3 Outline of Mammalian TrxR
3.3.1 Isoenzymes
3.3.2 Sec Incorporation
3.3.3 cDNAs and Genes
3.4 Regulation of Mammalian TrxR
3.4.1 Se-dependent Regulation
3.4.2 Regulation of Gene Expression
3.5 Structure
3.5.1 Functional Elements in Primary Structure
3.5.2 Functional Elements in Three-dimensional Structure
3.6 Proposed Mechanisms Underlying TrxR-I Catalysis
3.6.1 Electron Transfer Pathway
3.6.2 Acid-base Catalyst
3.6.3 Catalytic Roles of the Sec Residue
3.7 Roles of Mammalian TrxRs in Cell Growth and Apoptosis
3.7.1 Cross-talk with Glutathione System
3.7.2 Control of Cell Growth
3.7.3 Regulation of Apoptosis
References
4 Selenophosphate Synthetase
4.1 Introduction
4.2 Selenoprotein Biosynthesis in Prokaryotes
4.3 Structure of PurM Monomer and Selenophosphate Synthetase
4.3.1 Structure of PurM Monomer
4.3.2 Structure of Human SPS1
4.4 Cayalytic Mechanism of Selenophosphate Synthetase
4.5 SelD for Development and Cell Proliferation
4.6 Conclusion
References
5 Selenoprotein P
5.1 Introduction
5.2 Structural Features of SeP
5.2.1 Selenium Content of Human SeP
……
6 Selenoprotein T
7 Selenoprotein W
8 Selenoprotein Biosynthesis
9 Bioinformatics of Selenoproteins
10 Selenoproteins and Atherosclerosis
11 Selenoproteins and Brain Diseases
12 Selenoproteins and Thyroid Cancer
13 Selenoproteins and Selenium Speciation in Food
14 Synthetic Mimics of Selenoproteins
15 Cyclodextrin-based Mimics of Selenoproteins
16 Semisynthesized Selenoproteins
17 Selenium-containing Catalytic Antibodies
18 Biosynthetic Mimics of Selenoproteins
19 Nanoenzymes as Selenoprotein Mimics
20 Selenprotein Mimics and Diseases
Index
1.1 Introduction
1.2 Glutathione Peroxidase Reaction
1.2.1 Basic Catalytic Principle
1.2.2 Kinetics
1.2.3 Physiological Consequences of Kinetic Mechanism
1.2.4 Facts, Unknowns and Guesswork
1.3 Biological Roles of Individual Glutathione Peroxidases
1.3.1 GPx1
1.3.2 GPx2
1.3.3 GPx3
1.3.4 GPx4
1.3.5 GPx5-GPx8
1.4 Conclusions and Perspectives
References
2 Thyroid Hormone Deiodinases
2.1 Introduction
2.2 Thyroid Hormones
2.3 Deiodinases
2.3.1 Structure
2.3.2 Control
2.4 Role of Deiodinase in TH Actions
2.4.1 Photoperiod
2.4.2 Nutrition
2.4.3 Thermogenesis
2.4.4 Osmoregulation
2.4.5 Reproduction
2.4.6 Development, Including Metamorphosis
2.4.7 Developmental Genes
2.5 Evolution
References
3 Thioredoxin Reductase
3.1 Introduction
3.2 Selenium in Mammalian TrxR
3.3 Outline of Mammalian TrxR
3.3.1 Isoenzymes
3.3.2 Sec Incorporation
3.3.3 cDNAs and Genes
3.4 Regulation of Mammalian TrxR
3.4.1 Se-dependent Regulation
3.4.2 Regulation of Gene Expression
3.5 Structure
3.5.1 Functional Elements in Primary Structure
3.5.2 Functional Elements in Three-dimensional Structure
3.6 Proposed Mechanisms Underlying TrxR-I Catalysis
3.6.1 Electron Transfer Pathway
3.6.2 Acid-base Catalyst
3.6.3 Catalytic Roles of the Sec Residue
3.7 Roles of Mammalian TrxRs in Cell Growth and Apoptosis
3.7.1 Cross-talk with Glutathione System
3.7.2 Control of Cell Growth
3.7.3 Regulation of Apoptosis
References
4 Selenophosphate Synthetase
4.1 Introduction
4.2 Selenoprotein Biosynthesis in Prokaryotes
4.3 Structure of PurM Monomer and Selenophosphate Synthetase
4.3.1 Structure of PurM Monomer
4.3.2 Structure of Human SPS1
4.4 Cayalytic Mechanism of Selenophosphate Synthetase
4.5 SelD for Development and Cell Proliferation
4.6 Conclusion
References
5 Selenoprotein P
5.1 Introduction
5.2 Structural Features of SeP
5.2.1 Selenium Content of Human SeP
……
6 Selenoprotein T
7 Selenoprotein W
8 Selenoprotein Biosynthesis
9 Bioinformatics of Selenoproteins
10 Selenoproteins and Atherosclerosis
11 Selenoproteins and Brain Diseases
12 Selenoproteins and Thyroid Cancer
13 Selenoproteins and Selenium Speciation in Food
14 Synthetic Mimics of Selenoproteins
15 Cyclodextrin-based Mimics of Selenoproteins
16 Semisynthesized Selenoproteins
17 Selenium-containing Catalytic Antibodies
18 Biosynthetic Mimics of Selenoproteins
19 Nanoenzymes as Selenoprotein Mimics
20 Selenprotein Mimics and Diseases
Index
目 录内容简介
《硒蛋白及其模拟物(英文版)》是一本交叉学科的专著,邀请了国内外硒蛋白领域多位知名教授合作编写,将着重介绍各种硒蛋白的研究现状,特别是对近年来硒酶模拟化学和生物学相关研究进展进行全面综述。
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