Williams血液学（第9版）(英文版）
简 目
Contributors
Preface
PART IClinical Evaluation of the Patient
PARTII TheOrganization of the LymphohematopoieticTissues
PARTIII EpochalHematology
PARTIV Molecular and CellularHematology
PARTV TherapeuticPrinciples
PARTVI The Erythrocyte
查看完整
Contributors
Preface
PART IClinical Evaluation of the Patient
PARTII TheOrganization of the LymphohematopoieticTissues
PARTIII EpochalHematology
PARTIV Molecular and CellularHematology
PARTV TherapeuticPrinciples
PARTVI The Erythrocyte
查看完整
考杉斯基(Kaushansky)博士是纽约州立大学石溪分校健康科学院的高级副总裁，同时担任该校医学院院长的职务。考杉斯基(Kaushansky)博士是全球知名的血液学专家，发表过多篇有影响力的著作。担任《Willians血液学》第8版、第9版的主编。
《Williams血液学》是血液学领域的经典之作，涵盖了血液学的所有方面，介绍了患者临床评估、血液病的分子学和细胞学基础，并具体阐述了红细胞疾病、粒细胞和单核细胞疾病、淋巴细胞和浆细胞疾病、髓系肿瘤性疾病、淋巴组织疾病、止血和血栓、输血医学等内容。第9版在第8版的基础上做了大篇幅的修改和更新，以反映血液学领域的*进展。新增加了表观遗传学和基因组学、血液肿瘤细胞的新陈代谢和肝素诱导性血小板减少症等内容。本书是血液科临床医生、实习生、血液学研究人员必不可少的案头佳作，也是学习血液学专业英语的工具书。
简 目
Contributors
Preface
PART IClinical Evaluation of the Patient
PARTII TheOrganization of the LymphohematopoieticTissues
PARTIII EpochalHematology
PARTIV Molecular and CellularHematology
PARTV TherapeuticPrinciples
PARTVI The Erythrocyte
PARTVII Neutrophils,Eosinophils,Basophils, and Mast Cells
PARTVIII Monocytes and Macrophages
PARTIX Lymphocytes and Plasma Cells
PARTX MalignantMyeloid Diseases
PARTXI MalignantLymphoid Diseases
PARTXII Hemostasis andThrombosis
PARTXIII Transfusion Medicine
Index
v
目 录
Contributors. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .ix
Preface. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .xxi
PART I
ClinicalEvaluation of the Patient
1.InitialApproachto the Patient:HistoryandPhysicalExamination
2.Examinationof Blood Cells
3.ExaminationofTheMarrow
4.ConsultativeHematology
PART II
TheOrganization of the LymphohematopoieticTissues
5.Structureof the Marrowand the HematopoieticMicroenvironment
6.The Organization and StructureofLymphoid Tissues
PART III
Epochal Hematology
7.Hematologyof the FetusandNewborn
8.HematologyduringPregnancy
9.Hematology in OlderPersons
PART IV
Molecular and CellularHematology
10.Genetic PrinciplesandMolecular Biology
11.Genomics
12.Epigenetics
13.Cytogeneticsand Genetic Abnormalities
14.MetabolismofHematologicNeoplastic Cells
15.ApoptosisMechanisms:Relevanceto the HematopoieticSystem
16.Cell-CycleRegulationandHematologicDisorders
17.SignalTransductionPathways
18.HematopoieticStem Cells, Progenitors,andCytokines
19.TheInflammatory Response
20.InnateImmunity
21.Dendritic Cells andAdaptiveImmunity
PARTV
TherapeuticPrinciples
22.PharmacologyandToxicityofAntineoplastic Drugs
23.Hematopoietic Cell Transplantation
24.Treatment of InfectionsinTheImmunocompromisedHost
25.AntithromboticTherapy
26.Immune Cell Therapy
27.VaccineTherapy
28.TherapeuticApheresis:Indications,Efficacy,andComplications
29.Gene TherapyforHematologicDiseases
30.RegenerativeMedicine:MultipotentialCellTherapy for
TissueRepair
PARTVI
The Erythrocyte
31.StructureandCompositionof the Erythrocyte
32.Erythropoiesis
33.Erythrocyte Turnover
34.ClinicalManifestations and Classification ofErythrocyteDisorders
35.AplasticAnemia:Acquiredand Inherited.
36. Pure Red Cell Aplasia
37. Anemia of ChronicDisease
38. The Congenital DyserythropoieticAnemias
39. Paroxysmal Nocturnal Hemoglobinuria
40. ParoxysmalNocturnalHemoglobinuria
41. Folate,Cobalamin,andMegaloblasticAnemias
42.IronMetabolism
43.Iron Deficiency andOverload
44. Anemia Resulting fromOtherNutritionalDeficiencies
45. Anemia AssociatedwithMarrowInfiltration
46. Erythrocyte MembraneDisorders
47. Erythrocyte Enzyme Disorders
48. TheThalassemias: Disorders of GlobinSynthesis
49. DisordersofHemoglobinStructure:Sickle CellAnemiaandRelatedAbnormalities
50. Methemoglobinemiaand Other Dyshemoglobinemias
51. FragmentationHemolyticAnemia
52. Erythrocyte Disordersas a ResultofChemicalandPhysicalAgents
53. HemolyticAnemiaResultingfromInfectionswithMicroorganisms
54. HemolyticAnemiaResultingfromImmuneInjury
55. AlloimmuneHemolytic Disease of the FetusandNewborn
56. HypersplenismandHyposplenism
57. Primary and Secondary Erythrocytoses
58.ThePorphyrias
59.PolyclonalandHereditarySideroblasticAnemias
PARTVII
Neutrophils,Eosinophils,Basophils, and Mast Cells
60. StructureandCompositionofNeutrophils,Eosinophils,andBasophils
61. Production,Distribution,andFateofNeutrophils
62. EosinophilsandRelatedDisorders
63. Basophils,Mast Cells, andRelatedDisorders
64. Classificationand Clinical ManifestationsofNeutrophilDisorders
65. NeutropeniaandNeutrophilia
66. DisordersofNeutrophilFunction
PARTVIII
Monocytes and Macrophages
67. Structure,Receptors,andFunctionsofMonocytesandMacrophages
68. Production,Distribution,andActivationofMonocytesandMacrophages
69. Classificationand ClinicalManifestationsof DisordersofMonocytesandMacrophages
70. MonocytosisandMonocytopenia
71. Inflammatory andMalignantHistiocytosis
72. Gaucher Disease andRelatedLysosomalStorageDiseases
73. PART IX
Lymphocytes and Plasma Cells
73.The StructureofLymphocytes andPlasma Cells
74.LymphopoiesisFunctionsof B LymphocytesandPlasma Cells inImmunoglobulinProduction
75. Functionsof T Lymphocytes:T-CellReceptorsforAntigen
76. FunctionsofNaturalKiller Cells
77. Classificationand Clinical ManifestationsofLymphocyteandPlasma Cell Disorders
79.LymphocytosisandLymphocytopenia
80.Immunodeficiency Diseases
81.HematologicManifestationsofAcquiredImmunodeficiencySyndrome
82.MononucleosisSyndromes
PART X
MalignantMyeloid Diseases
83.Classification and ClinicalManifestationsoftheClonalMyeloidDisorders
84.PolycythemiaVera
85.EssentialThrombocythemia
86.Primary Myelofibrosis
87.MyelodysplasticSyndromes
88.AcuteMyelogenousLeukemia
89.ChronicMyelogenousLeukemiaandRelatedDisorders
PART XI
MalignantLymphoid Diseases
90.ClassificationofMalignantLymphoid Disorders
91.AcuteLymphoblasticLeukemia
92.ChronicLymphocyticLeukemia
93.Hairy Cell Leukemia
94.LargeGranularLymphocyticLeukemia
95.General ConsiderationsforLymphomas:Epidemiology,Etiology,Heterogeneity,and Primary Extranodal Disease
96.PathologyofLymphomas.
97.HodgkinLymphoma
98.Diffuse Large B-Cell Lymphoma andRelated Diseases
99.FollicularLymphoma
100.Mantle Cell Lymphoma
101.MarginalZone B-Cell Lymphomas
102.BurkittLymphoma
103.CutaneousT-CellLymphoma(MycosisFungoidesandSézarySyndrome)
104.MatureT-CellandNaturalKiller Cell Lymphomas
105.Plasma Cell Neoplasms: General Considerations
106.EssentialMonoclonalGammopathy
107.Myeloma.
108.ImmunoglobulinLight-ChainAmyloidosis
109.Macroglobulinemia.
110.Heavy-Chain Disease
PART XII
Hemostasis andThrombosis
111.Megakaryopoiesis andThrombopoiesis
112.PlateletMorphology,Biochemistry,and Function
113.Molecular Biology andBiochemistryof theCoagulationFactorsandPathwaysofHemostasis
114.ControlofCoagulationReactions
115.VascularFunction in Hemostasis
116.Classification, Clinical Manifestations, andEvaluationofDisordersofHemostasis
117.Thrombocytopenia
118.Heparin-Induced Thrombocytopenia
119.ReactiveThrombocytosis
120.HereditaryQualitativePlateletDisorders
121.AcquiredQualitativePlateletDisorders
122.TheVascularPurpuras
123. Hemophilia A andHemophilia B
124. InheritedDeficiencies of Coagulation FactorsII,V,V VIII, VII, X, XI, and XII
125. Hereditary Fibrinogen Abnormalities
126. von Willebrand Disease
127. Antibody-Mediated Coagulation FactorDeficiencies
128. HemostaticAlterations in Liver Disease andLiverTransplantation
129. DisseminatedIntravascularCoagulation
130.HereditaryThrombophilia
131. The AntiphospholipidSyndrome
132. Thrombotic Microangiopathies
133.VenousThrombosis
134. Atherothrombosis: Disease Initiation,Progression,andTreatment
135. Fibrinolysis andThrombolysis
PART XIII
Transfusion Medicine
136. Erythrocyte AntigensandAntibodies
137. Human Leukocyte andPlateletAntigens
138. Blood Procurementand Red Cell Transfusion
139. Preservationand Clinical UseofPlatelets
Index
^ 收 起
Contributors
Preface
PART IClinical Evaluation of the Patient
PARTII TheOrganization of the LymphohematopoieticTissues
PARTIII EpochalHematology
PARTIV Molecular and CellularHematology
PARTV TherapeuticPrinciples
PARTVI The Erythrocyte
PARTVII Neutrophils,Eosinophils,Basophils, and Mast Cells
PARTVIII Monocytes and Macrophages
PARTIX Lymphocytes and Plasma Cells
PARTX MalignantMyeloid Diseases
PARTXI MalignantLymphoid Diseases
PARTXII Hemostasis andThrombosis
PARTXIII Transfusion Medicine
Index
v
目 录
Contributors. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .ix
Preface. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .xxi
PART I
ClinicalEvaluation of the Patient
1.InitialApproachto the Patient:HistoryandPhysicalExamination
2.Examinationof Blood Cells
3.ExaminationofTheMarrow
4.ConsultativeHematology
PART II
TheOrganization of the LymphohematopoieticTissues
5.Structureof the Marrowand the HematopoieticMicroenvironment
6.The Organization and StructureofLymphoid Tissues
PART III
Epochal Hematology
7.Hematologyof the FetusandNewborn
8.HematologyduringPregnancy
9.Hematology in OlderPersons
PART IV
Molecular and CellularHematology
10.Genetic PrinciplesandMolecular Biology
11.Genomics
12.Epigenetics
13.Cytogeneticsand Genetic Abnormalities
14.MetabolismofHematologicNeoplastic Cells
15.ApoptosisMechanisms:Relevanceto the HematopoieticSystem
16.Cell-CycleRegulationandHematologicDisorders
17.SignalTransductionPathways
18.HematopoieticStem Cells, Progenitors,andCytokines
19.TheInflammatory Response
20.InnateImmunity
21.Dendritic Cells andAdaptiveImmunity
PARTV
TherapeuticPrinciples
22.PharmacologyandToxicityofAntineoplastic Drugs
23.Hematopoietic Cell Transplantation
24.Treatment of InfectionsinTheImmunocompromisedHost
25.AntithromboticTherapy
26.Immune Cell Therapy
27.VaccineTherapy
28.TherapeuticApheresis:Indications,Efficacy,andComplications
29.Gene TherapyforHematologicDiseases
30.RegenerativeMedicine:MultipotentialCellTherapy for
TissueRepair
PARTVI
The Erythrocyte
31.StructureandCompositionof the Erythrocyte
32.Erythropoiesis
33.Erythrocyte Turnover
34.ClinicalManifestations and Classification ofErythrocyteDisorders
35.AplasticAnemia:Acquiredand Inherited.
36. Pure Red Cell Aplasia
37. Anemia of ChronicDisease
38. The Congenital DyserythropoieticAnemias
39. Paroxysmal Nocturnal Hemoglobinuria
40. ParoxysmalNocturnalHemoglobinuria
41. Folate,Cobalamin,andMegaloblasticAnemias
42.IronMetabolism
43.Iron Deficiency andOverload
44. Anemia Resulting fromOtherNutritionalDeficiencies
45. Anemia AssociatedwithMarrowInfiltration
46. Erythrocyte MembraneDisorders
47. Erythrocyte Enzyme Disorders
48. TheThalassemias: Disorders of GlobinSynthesis
49. DisordersofHemoglobinStructure:Sickle CellAnemiaandRelatedAbnormalities
50. Methemoglobinemiaand Other Dyshemoglobinemias
51. FragmentationHemolyticAnemia
52. Erythrocyte Disordersas a ResultofChemicalandPhysicalAgents
53. HemolyticAnemiaResultingfromInfectionswithMicroorganisms
54. HemolyticAnemiaResultingfromImmuneInjury
55. AlloimmuneHemolytic Disease of the FetusandNewborn
56. HypersplenismandHyposplenism
57. Primary and Secondary Erythrocytoses
58.ThePorphyrias
59.PolyclonalandHereditarySideroblasticAnemias
PARTVII
Neutrophils,Eosinophils,Basophils, and Mast Cells
60. StructureandCompositionofNeutrophils,Eosinophils,andBasophils
61. Production,Distribution,andFateofNeutrophils
62. EosinophilsandRelatedDisorders
63. Basophils,Mast Cells, andRelatedDisorders
64. Classificationand Clinical ManifestationsofNeutrophilDisorders
65. NeutropeniaandNeutrophilia
66. DisordersofNeutrophilFunction
PARTVIII
Monocytes and Macrophages
67. Structure,Receptors,andFunctionsofMonocytesandMacrophages
68. Production,Distribution,andActivationofMonocytesandMacrophages
69. Classificationand ClinicalManifestationsof DisordersofMonocytesandMacrophages
70. MonocytosisandMonocytopenia
71. Inflammatory andMalignantHistiocytosis
72. Gaucher Disease andRelatedLysosomalStorageDiseases
73. PART IX
Lymphocytes and Plasma Cells
73.The StructureofLymphocytes andPlasma Cells
74.LymphopoiesisFunctionsof B LymphocytesandPlasma Cells inImmunoglobulinProduction
75. Functionsof T Lymphocytes:T-CellReceptorsforAntigen
76. FunctionsofNaturalKiller Cells
77. Classificationand Clinical ManifestationsofLymphocyteandPlasma Cell Disorders
79.LymphocytosisandLymphocytopenia
80.Immunodeficiency Diseases
81.HematologicManifestationsofAcquiredImmunodeficiencySyndrome
82.MononucleosisSyndromes
PART X
MalignantMyeloid Diseases
83.Classification and ClinicalManifestationsoftheClonalMyeloidDisorders
84.PolycythemiaVera
85.EssentialThrombocythemia
86.Primary Myelofibrosis
87.MyelodysplasticSyndromes
88.AcuteMyelogenousLeukemia
89.ChronicMyelogenousLeukemiaandRelatedDisorders
PART XI
MalignantLymphoid Diseases
90.ClassificationofMalignantLymphoid Disorders
91.AcuteLymphoblasticLeukemia
92.ChronicLymphocyticLeukemia
93.Hairy Cell Leukemia
94.LargeGranularLymphocyticLeukemia
95.General ConsiderationsforLymphomas:Epidemiology,Etiology,Heterogeneity,and Primary Extranodal Disease
96.PathologyofLymphomas.
97.HodgkinLymphoma
98.Diffuse Large B-Cell Lymphoma andRelated Diseases
99.FollicularLymphoma
100.Mantle Cell Lymphoma
101.MarginalZone B-Cell Lymphomas
102.BurkittLymphoma
103.CutaneousT-CellLymphoma(MycosisFungoidesandSézarySyndrome)
104.MatureT-CellandNaturalKiller Cell Lymphomas
105.Plasma Cell Neoplasms: General Considerations
106.EssentialMonoclonalGammopathy
107.Myeloma.
108.ImmunoglobulinLight-ChainAmyloidosis
109.Macroglobulinemia.
110.Heavy-Chain Disease
PART XII
Hemostasis andThrombosis
111.Megakaryopoiesis andThrombopoiesis
112.PlateletMorphology,Biochemistry,and Function
113.Molecular Biology andBiochemistryof theCoagulationFactorsandPathwaysofHemostasis
114.ControlofCoagulationReactions
115.VascularFunction in Hemostasis
116.Classification, Clinical Manifestations, andEvaluationofDisordersofHemostasis
117.Thrombocytopenia
118.Heparin-Induced Thrombocytopenia
119.ReactiveThrombocytosis
120.HereditaryQualitativePlateletDisorders
121.AcquiredQualitativePlateletDisorders
122.TheVascularPurpuras
123. Hemophilia A andHemophilia B
124. InheritedDeficiencies of Coagulation FactorsII,V,V VIII, VII, X, XI, and XII
125. Hereditary Fibrinogen Abnormalities
126. von Willebrand Disease
127. Antibody-Mediated Coagulation FactorDeficiencies
128. HemostaticAlterations in Liver Disease andLiverTransplantation
129. DisseminatedIntravascularCoagulation
130.HereditaryThrombophilia
131. The AntiphospholipidSyndrome
132. Thrombotic Microangiopathies
133.VenousThrombosis
134. Atherothrombosis: Disease Initiation,Progression,andTreatment
135. Fibrinolysis andThrombolysis
PART XIII
Transfusion Medicine
136. Erythrocyte AntigensandAntibodies
137. Human Leukocyte andPlateletAntigens
138. Blood Procurementand Red Cell Transfusion
139. Preservationand Clinical UseofPlatelets
Index
^ 收 起
考杉斯基(Kaushansky)博士是纽约州立大学石溪分校健康科学院的高级副总裁，同时担任该校医学院院长的职务。考杉斯基(Kaushansky)博士是全球知名的血液学专家，发表过多篇有影响力的著作。担任《Willians血液学》第8版、第9版的主编。
《Williams血液学》是血液学领域的经典之作，涵盖了血液学的所有方面，介绍了患者临床评估、血液病的分子学和细胞学基础，并具体阐述了红细胞疾病、粒细胞和单核细胞疾病、淋巴细胞和浆细胞疾病、髓系肿瘤性疾病、淋巴组织疾病、止血和血栓、输血医学等内容。第9版在第8版的基础上做了大篇幅的修改和更新，以反映血液学领域的*进展。新增加了表观遗传学和基因组学、血液肿瘤细胞的新陈代谢和肝素诱导性血小板减少症等内容。本书是血液科临床医生、实习生、血液学研究人员必不可少的案头佳作，也是学习血液学专业英语的工具书。
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